The emergence of diverse generative vision models has recently enabled the synthesis of visually realistic images, underscoring the critical need for effectively detecting these generated images from real photos. Despite advances in this field, existing detection approaches often struggle to accurately identify synthesized images generated by different generative models. In this work, we introduce a novel and generalizable detection framework termed HyperDet, which innovatively captures and integrates shared knowledge from a collection of functionally distinct and lightweight expert detectors. HyperDet leverages a large pretrained vision model to extract general detection features while simultaneously capturing and enhancing task-specific features. To achieve this, HyperDet first groups SRM filters into five distinct groups to efficiently capture varying levels of pixel artifacts based on their different functionality and complexity. Then, HyperDet utilizes a hypernetwork to generate LoRA model weights with distinct embedding parameters. Finally, we merge the LoRA networks to form an efficient model ensemble. Also, we propose a novel objective function that balances the pixel and semantic artifacts effectively. Extensive experiments on the UnivFD and Fake2M datasets demonstrate the effectiveness of our approach, achieving state-of-the-art performance. Moreover, our work paves a new way to establish generalizable domain-specific fake image detectors based on pretrained large vision models.