Despite their superb multimodal capabilities, Vision-Language Models (VLMs) have been shown to be vulnerable to jailbreak attacks, which are inference-time attacks that induce the model to output harmful responses with tricky prompts. It is thus essential to defend VLMs against potential jailbreaks for their trustworthy deployment in real-world applications. In this work, we focus on black-box defense for VLMs against jailbreak attacks. Existing black-box defense methods are either unimodal or bimodal. Unimodal methods enhance either the vision or language module of the VLM, while bimodal methods robustify the model through text-image representation realignment. However, these methods suffer from two limitations: 1) they fail to fully exploit the cross-modal information, or 2) they degrade the model performance on benign inputs. To address these limitations, we propose a novel blue-team method BlueSuffix that defends the black-box target VLM against jailbreak attacks without compromising its performance. BlueSuffix includes three key components: 1) a visual purifier against jailbreak images, 2) a textual purifier against jailbreak texts, and 3) a blue-team suffix generator fine-tuned via reinforcement learning for enhancing cross-modal robustness. We empirically show on three VLMs (LLaVA, MiniGPT-4, and Gemini) and two safety benchmarks (MM-SafetyBench and RedTeam-2K) that BlueSuffix outperforms the baseline defenses by a significant margin. Our BlueSuffix opens up a promising direction for defending VLMs against jailbreak attacks.