This study provides a new understanding of the adversarial attack problem by examining the correlation between adversarial attack and visual attention change. In particular, we observed that: (1) images with incomplete attention regions are more vulnerable to adversarial attacks; and (2) successful adversarial attacks lead to deviated and scattered attention map. Accordingly, an attention-based adversarial defense framework is designed to simultaneously rectify the attention map for prediction and preserve the attention area between adversarial and original images. The problem of adding iteratively attacked samples is also discussed in the context of visual attention change. We hope the attention-related data analysis and defense solution in this study will shed some light on the mechanism behind the adversarial attack and also facilitate future adversarial defense/attack model design.