Multimodal large language models (MLLMs) have made remarkable strides in cross-modal comprehension and generation tasks. However, they remain vulnerable to jailbreak attacks, where crafted perturbations bypass security guardrails and elicit harmful outputs. In this paper, we present the first adversarial training (AT) paradigm tailored to defend against jailbreak attacks during the MLLM training phase. Extending traditional AT to this domain poses two critical challenges: efficiently tuning massive parameters and ensuring robustness against attacks across multiple modalities. To address these challenges, we introduce Projection Layer Against Adversarial Training (ProEAT), an end-to-end AT framework. ProEAT incorporates a projector-based adversarial training architecture that efficiently handles large-scale parameters while maintaining computational feasibility by focusing adversarial training on a lightweight projector layer instead of the entire model; additionally, we design a dynamic weight adjustment mechanism that optimizes the loss function's weight allocation based on task demands, streamlining the tuning process. To enhance defense performance, we propose a joint optimization strategy across visual and textual modalities, ensuring robust resistance to jailbreak attacks originating from either modality. Extensive experiments conducted on five major jailbreak attack methods across three mainstream MLLMs demonstrate the effectiveness of our approach. ProEAT achieves state-of-the-art defense performance, outperforming existing baselines by an average margin of +34% across text and image modalities, while incurring only a 1% reduction in clean accuracy. Furthermore, evaluations on real-world embodied intelligent systems highlight the practical applicability of our framework, paving the way for the development of more secure and reliable multimodal systems.