DSCENet: Dynamic Screening and Clinical-Enhanced Multimodal Fusion for MPNs Subtype Classification

The precise subtype classification of myeloproliferative neoplasms (MPNs) based on multimodal information, which assists clinicians in diagnosis and long-term treatment plans, is of great clinical significance. However, it remains a great challenging task due to the lack of diagnostic representativeness for local patches and the absence of diagnostic-relevant features from a single modality. In this paper, we propose a Dynamic Screening and Clinical-Enhanced Network (DSCENet) for the subtype classification of MPNs on the multimodal fusion of whole slide images (WSIs) and clinical information. (1) A dynamic screening module is proposed to flexibly adapt the feature learning of local patches, reducing the interference of irrelevant features and enhancing their diagnostic representativeness. (2) A clinical-enhanced fusion module is proposed to integrate clinical indicators to explore complementary features across modalities, providing comprehensive diagnostic information. Our approach has been validated on the real clinical data, achieving an increase of 7.91% AUC and 16.89% accuracy compared with the previous state-of-the-art (SOTA) methods. The code is available at https://github.com/yuanzhang7/DSCENet.

FedSODA: Federated Cross-assessment and Dynamic Aggregation for Histopathology Segmentation

Federated learning (FL) for histopathology image segmentation involving multiple medical sites plays a crucial role in advancing the field of accurate disease diagnosis and treatment. However, it is still a task of great challenges due to the sample imbalance across clients and large data heterogeneity from disparate organs, variable segmentation tasks, and diverse distribution. Thus, we propose a novel FL approach for histopathology nuclei and tissue segmentation, FedSODA, via synthetic-driven cross-assessment operation (SO) and dynamic stratified-layer aggregation (DA). Our SO constructs a cross-assessment strategy to connect clients and mitigate the representation bias under sample imbalance. Our DA utilizes layer-wise interaction and dynamic aggregation to diminish heterogeneity and enhance generalization. The effectiveness of our FedSODA has been evaluated on the most extensive histopathology image segmentation dataset from 7 independent datasets. The code is available at https://github.com/yuanzhang7/FedSODA.