ClinicalGPT-R1: Pushing reasoning capability of generalist disease diagnosis with large language model

Recent advances in reasoning with large language models (LLMs)has shown remarkable reasoning capabilities in domains such as mathematics and coding, yet their application to clinical diagnosis remains underexplored. Here, we introduce ClinicalGPT-R1, a reasoning enhanced generalist large language model for disease diagnosis. Trained on a dataset of 20,000 real-world clinical records, ClinicalGPT-R1 leverages diverse training strategies to enhance diagnostic reasoning. To benchmark performance, we curated MedBench-Hard, a challenging dataset spanning seven major medical specialties and representative diseases. Experimental results demonstrate that ClinicalGPT-R1 outperforms GPT-4o in Chinese diagnostic tasks and achieves comparable performance to GPT-4 in English settings. This comparative study effectively validates the superior performance of ClinicalGPT-R1 in disease diagnosis tasks. Resources are available at https://github.com/medfound/medfound.

Training Spiking Neural Networks via Augmented Direct Feedback Alignment

Spiking neural networks (SNNs), the models inspired by the mechanisms of real neurons in the brain, transmit and represent information by employing discrete action potentials or spikes. The sparse, asynchronous properties of information processing make SNNs highly energy efficient, leading to SNNs being promising solutions for implementing neural networks in neuromorphic devices. However, the nondifferentiable nature of SNN neurons makes it a challenge to train them. The current training methods of SNNs that are based on error backpropagation (BP) and precisely designing surrogate gradient are difficult to implement and biologically implausible, hindering the implementation of SNNs on neuromorphic devices. Thus, it is important to train SNNs with a method that is both physically implementatable and biologically plausible. In this paper, we propose using augmented direct feedback alignment (aDFA), a gradient-free approach based on random projection, to train SNNs. This method requires only partial information of the forward process during training, so it is easy to implement and biologically plausible. We systematically demonstrate the feasibility of the proposed aDFA-SNNs scheme, propose its effective working range, and analyze its well-performing settings by employing genetic algorithm. We also analyze the impact of crucial features of SNNs on the scheme, thus demonstrating its superiority and stability over BP and conventional direct feedback alignment. Our scheme can achieve competitive performance without accurate prior knowledge about the utilized system, thus providing a valuable reference for physically training SNNs.