Abstract:The computer-aided diagnosis (CAD) system can provide a reference basis for the clinical diagnosis of skin diseases. Convolutional neural networks (CNNs) can not only extract visual elements such as colors and shapes but also semantic features. As such they have made great improvements in many tasks of dermoscopy images. The imaging of dermoscopy has no main direction, indicating that there are a large number of skin lesion target rotations in the datasets. However, CNNs lack anti-rotation ability, which is bound to affect the feature extraction ability of CNNs. We propose a rotation meanout (RM) network to extract rotation invariance features from dermoscopy images. In RM, each set of rotated feature maps corresponds to a set of weight-sharing convolution outputs and they are fused using meanout operation to obtain the final feature maps. Through theoretical derivation, the proposed RM network is rotation-equivariant and can extract rotation-invariant features when being followed by the global average pooling (GAP) operation. The extracted rotation-invariant features can better represent the original data in classification and retrieval tasks for dermoscopy images. The proposed RM is a general operation, which does not change the network structure or increase any parameter, and can be flexibly embedded in any part of CNNs. Extensive experiments are conducted on a dermoscopy image dataset. The results show our method outperforms other anti-rotation methods and achieves great improvements in dermoscopy image classification and retrieval tasks, indicating the potential of rotation invariance in the field of dermoscopy images.