Multiple Instance Learning Framework with Masked Hard Instance Mining for Whole Slide Image Classification

The whole slide image (WSI) classification is often formulated as a multiple instance learning (MIL) problem. Since the positive tissue is only a small fraction of the gigapixel WSI, existing MIL methods intuitively focus on identifying salient instances via attention mechanisms. However, this leads to a bias towards easy-to-classify instances while neglecting hard-to-classify instances. Some literature has revealed that hard examples are beneficial for modeling a discriminative boundary accurately. By applying such an idea at the instance level, we elaborate a novel MIL framework with masked hard instance mining (MHIM-MIL), which uses a Siamese structure (Teacher-Student) with a consistency constraint to explore the potential hard instances. With several instance masking strategies based on attention scores, MHIM-MIL employs a momentum teacher to implicitly mine hard instances for training the student model, which can be any attention-based MIL model. This counter-intuitive strategy essentially enables the student to learn a better discriminating boundary. Moreover, the student is used to update the teacher with an exponential moving average (EMA), which in turn identifies new hard instances for subsequent training iterations and stabilizes the optimization. Experimental results on the CAMELYON-16 and TCGA Lung Cancer datasets demonstrate that MHIM-MIL outperforms other latest methods in terms of performance and training cost. The code is available at: https://github.com/DearCaat/MHIM-MIL.

PicT: A Slim Weakly Supervised Vision Transformer for Pavement Distress Classification

Automatic pavement distress classification facilitates improving the efficiency of pavement maintenance and reducing the cost of labor and resources. A recently influential branch of this task divides the pavement image into patches and addresses these issues from the perspective of multi-instance learning. However, these methods neglect the correlation between patches and suffer from a low efficiency in the model optimization and inference. Meanwhile, Swin Transformer is able to address both of these issues with its unique strengths. Built upon Swin Transformer, we present a vision Transformer named \textbf{P}avement \textbf{I}mage \textbf{C}lassification \textbf{T}ransformer (\textbf{PicT}) for pavement distress classification. In order to better exploit the discriminative information of pavement images at the patch level, the \textit{Patch Labeling Teacher} is proposed to leverage a teacher model to dynamically generate pseudo labels of patches from image labels during each iteration, and guides the model to learn the discriminative features of patches. The broad classification head of Swin Transformer may dilute the discriminative features of distressed patches in the feature aggregation step due to the small distressed area ratio of the pavement image. To overcome this drawback, we present a \textit{Patch Refiner} to cluster patches into different groups and only select the highest distress-risk group to yield a slim head for the final image classification. We evaluate our method on CQU-BPDD. Extensive results show that \textbf{PicT} outperforms the second-best performed model by a large margin of $+2.4\%$ in P@R on detection task, $+3.9\%$ in $F1$ on recognition task, and 1.8x throughput, while enjoying 7x faster training speed using the same computing resources. Our codes and models have been released on \href{https://github.com/DearCaat/PicT}{https://github.com/DearCaat/PicT}.