Evaluating Performance of Machine Learning Models for Diabetic Sensorimotor Polyneuropathy Severity Classification using Biomechanical Signals during Gait

Diabetic sensorimotor polyneuropathy (DSPN) is one of the prevalent forms of neuropathy affected by diabetic patients that involves alterations in biomechanical changes in human gait. In literature, for the last 50 years, researchers are trying to observe the biomechanical changes due to DSPN by studying muscle electromyography (EMG), and ground reaction forces (GRF). However, the literature is contradictory. In such a scenario, we are proposing to use Machine learning techniques to identify DSPN patients by using EMG, and GRF data. We have collected a dataset consists of three lower limb muscles EMG (tibialis anterior (TA), vastus lateralis (VL), gastrocnemius medialis (GM) and 3-dimensional GRF components (GRFx, GRFy, and GRFz). Raw EMG and GRF signals were preprocessed, and a newly proposed feature extraction technique scheme from literature was applied to extract the best features from the signals. The extracted feature list was ranked using Relief feature ranking techniques, and highly correlated features were removed. We have trained different ML models to find out the best-performing model and optimized that model. We trained the optimized ML models for different combinations of muscles and GRF components features, and the performance matrix was evaluated. This study has found ensemble classifier model was performing in identifying DSPN Severity, and we optimized it before training. For EMG analysis, we have found the best accuracy of 92.89% using the Top 14 features for features from GL, VL and TA muscles combined. In the GRF analysis, the model showed 94.78% accuracy by using the Top 15 features for the feature combinations extracted from GRFx, GRFy and GRFz signals. The performance of ML-based DSPN severity classification models, improved significantly, indicating their reliability in DSPN severity classification, for biomechanical data.

A Machine Learning Model for Early Detection of Diabetic Foot using Thermogram Images

Diabetes foot ulceration (DFU) and amputation are a cause of significant morbidity. The prevention of DFU may be achieved by the identification of patients at risk of DFU and the institution of preventative measures through education and offloading. Several studies have reported that thermogram images may help to detect an increase in plantar temperature prior to DFU. However, the distribution of plantar temperature may be heterogeneous, making it difficult to quantify and utilize to predict outcomes. We have compared a machine learning-based scoring technique with feature selection and optimization techniques and learning classifiers to several state-of-the-art Convolutional Neural Networks (CNNs) on foot thermogram images and propose a robust solution to identify the diabetic foot. A comparatively shallow CNN model, MobilenetV2 achieved an F1 score of ~95% for a two-feet thermogram image-based classification and the AdaBoost Classifier used 10 features and achieved an F1 score of 97 %. A comparison of the inference time for the best-performing networks confirmed that the proposed algorithm can be deployed as a smartphone application to allow the user to monitor the progression of the DFU in a home setting.