Ptychographic Image Reconstruction from Limited Data via Score-Based Diffusion Models with Physics-Guidance

Ptychography is a computational imaging technique that achieves high spatial resolution over large fields of view. It involves scanning a coherent beam across overlapping regions and recording diffraction patterns. Conventional reconstruction algorithms require substantial overlap, increasing data volume and experimental time. We propose a reconstruction method employing a physics-guided score-based diffusion model. Our approach trains a diffusion model on representative object images to learn an object distribution prior. During reconstruction, we modify the reverse diffusion process to enforce data consistency, guiding reverse diffusion toward a physically plausible solution. This method requires a single pretraining phase, allowing it to generalize across varying scan overlap ratios and positions. Our results demonstrate that the proposed method achieves high-fidelity reconstructions with only a 20% overlap, while the widely employed rPIE method requires a 62% overlap to achieve similar accuracy. This represents a significant reduction in data requirements, offering an alternative to conventional techniques.

Learning a Filtered Backprojection Reconstruction Method for Photoacoustic Computed Tomography with Hemispherical Measurement Geometries

In certain three-dimensional (3D) applications of photoacoustic computed tomography (PACT), including \textit{in vivo} breast imaging, hemispherical measurement apertures that enclose the object within their convex hull are employed for data acquisition. Data acquired with such measurement geometries are referred to as \textit{half-scan} data, as only half of a complete spherical measurement aperture is employed. Although previous studies have demonstrated that half-scan data can uniquely and stably reconstruct the sought-after object, no closed-form reconstruction formula for use with half-scan data has been reported. To address this, a semi-analytic reconstruction method in the form of filtered backprojection (FBP), referred to as the half-scan FBP method, is developed in this work. Because the explicit form of the filtering operation in the half-scan FBP method is not currently known, a learning-based method is proposed to approximate it. The proposed method is systematically investigated by use of virtual imaging studies of 3D breast PACT that employ ensembles of numerical breast phantoms and a physics-based model of the data acquisition process. The method is subsequently applied to experimental data acquired in an \textit{in vivo} breast PACT study. The results confirm that the half-scan FBP method can accurately reconstruct 3D images from half-scan data. Importantly, because the sought-after inverse mapping is well-posed, the reconstruction method remains accurate even when applied to data that differ considerably from those employed to learn the filtering operation.

ProxNF: Neural Field Proximal Training for High-Resolution 4D Dynamic Image Reconstruction

Accurate spatiotemporal image reconstruction methods are needed for a wide range of biomedical research areas but face challenges due to data incompleteness and computational burden. Data incompleteness arises from the undersampling often required to increase frame rates and reduce acquisition times, while computational burden emerges due to the memory footprint of high-resolution images with three spatial dimensions and extended time horizons. Neural fields, an emerging class of neural networks that act as continuous representations of spatiotemporal objects, have previously been introduced to solve these dynamic imaging problems by reframing image reconstruction to a problem of estimating network parameters. Neural fields can address the twin challenges of data incompleteness and computational burden by exploiting underlying redundancies in these spatiotemporal objects. This work proposes ProxNF, a novel neural field training approach for spatiotemporal image reconstruction leveraging proximal splitting methods to separate computations involving the imaging operator from updates of the network parameter. Specifically, ProxNF evaluates the (subsampled) gradient of the data-fidelity term in the image domain and uses a fully supervised learning approach to update the neural field parameters. By reducing the memory footprint and the computational cost of evaluating the imaging operator, the proposed ProxNF approach allows for reconstructing large, high-resolution spatiotemporal images. This method is demonstrated in two numerical studies involving virtual dynamic contrast-enhanced photoacoustic computed tomography imaging of an anatomically realistic dynamic numerical mouse phantom and a two-compartment model of tumor perfusion.

Technical Note: An Efficient Implementation of the Spherical Radon Transform with Cylindrical Apertures

The spherical Radon transform (SRT) is an integral transform that maps a function to its integrals over concentric spherical shells centered at specified sensor locations. It has several imaging applications, including synthetic aperture radar and photoacoustic computed tomography. However, computation of the SRT can be expensive. Efficient implementation of SRT on general purpose graphic processing units (GPGPUs) often utilizes non-matched implementation of the adjoint operator, leading to inconsistent gradients in optimization-based image reconstruction methods. This work details an efficient implementation of the SRT and its adjoint for the case of a cylindrical measurement aperture. Exploiting symmetry of the cylindrical geometry, the SRT can then be expressed as the composition of two circular Radon transforms (CRT). Utilizing this formulation then allows for an efficient implementation of the SRT as a discrete-to-discrete operator utilizing sparse matrix representation.