Leveraging Large Language Models for Medical Information Extraction and Query Generation

This paper introduces a system that integrates large language models (LLMs) into the clinical trial retrieval process, enhancing the effectiveness of matching patients with eligible trials while maintaining information privacy and allowing expert oversight. We evaluate six LLMs for query generation, focusing on open-source and relatively small models that require minimal computational resources. Our evaluation includes two closed-source and four open-source models, with one specifically trained in the medical field and five general-purpose models. We compare the retrieval effectiveness achieved by LLM-generated queries against those created by medical experts and state-of-the-art methods from the literature. Our findings indicate that the evaluated models reach retrieval effectiveness on par with or greater than expert-created queries. The LLMs consistently outperform standard baselines and other approaches in the literature. The best performing LLMs exhibit fast response times, ranging from 1.7 to 8 seconds, and generate a manageable number of query terms (15-63 on average), making them suitable for practical implementation. Our overall findings suggest that leveraging small, open-source LLMs for clinical trials retrieval can balance performance, computational efficiency, and real-world applicability in medical settings.

DESIRE-ME: Domain-Enhanced Supervised Information REtrieval using Mixture-of-Experts

Open-domain question answering requires retrieval systems able to cope with the diverse and varied nature of questions, providing accurate answers across a broad spectrum of query types and topics. To deal with such topic heterogeneity through a unique model, we propose DESIRE-ME, a neural information retrieval model that leverages the Mixture-of-Experts framework to combine multiple specialized neural models. We rely on Wikipedia data to train an effective neural gating mechanism that classifies the incoming query and that weighs the predictions of the different domain-specific experts correspondingly. This allows DESIRE-ME to specialize adaptively in multiple domains. Through extensive experiments on publicly available datasets, we show that our proposal can effectively generalize domain-enhanced neural models. DESIRE-ME excels in handling open-domain questions adaptively, boosting by up to 12% in NDCG@10 and 22% in P@1, the underlying state-of-the-art dense retrieval model.

SE-PEF: a Resource for Personalized Expert Finding

The problem of personalization in Information Retrieval has been under study for a long time. A well-known issue related to this task is the lack of publicly available datasets that can support a comparative evaluation of personalized search systems. To contribute in this respect, this paper introduces SE-PEF (StackExchange - Personalized Expert Finding), a resource useful for designing and evaluating personalized models related to the task of Expert Finding (EF). The contributed dataset includes more than 250k queries and 565k answers from 3 306 experts, which are annotated with a rich set of features modeling the social interactions among the users of a popular cQA platform. The results of the preliminary experiments conducted show the appropriateness of SE-PEF to evaluate and to train effective EF models.

Denoising Attention for Query-aware User Modeling in Personalized Search

The personalization of search results has gained increasing attention in the past few years, thanks to the development of Neural Networks-based approaches for Information Retrieval and the importance of personalization in many search scenarios. Recent works have proposed to build user models at query time by leveraging the Attention mechanism, which allows weighing the contribution of the user-related information w.r.t. the current query. This approach allows taking into account the diversity of the user's interests by giving more importance to those related to the current search performed by the user. In this paper, we first discuss some shortcomings of the standard Attention formulation when employed for personalization. In particular, we focus on issues related to its normalization mechanism and its inability to entirely filter out noisy user-related information. Then, we introduce the Denoising Attention mechanism: an Attention variant that directly tackles the above shortcomings by adopting a robust normalization scheme and introducing a filtering mechanism. The reported experimental evaluation shows the benefits of the proposed approach over other Attention-based variants.

SE-PQA: Personalized Community Question Answering

Personalization in Information Retrieval is a topic studied for a long time. Nevertheless, there is still a lack of high-quality, real-world datasets to conduct large-scale experiments and evaluate models for personalized search. This paper contributes to filling this gap by introducing SE-PQA (StackExchange - Personalized Question Answering), a new curated resource to design and evaluate personalized models related to the task of community Question Answering (cQA). The contributed dataset includes more than 1 million queries and 2 million answers, annotated with a rich set of features modeling the social interactions among the users of a popular cQA platform. We describe the characteristics of SE-PQA and detail the features associated with questions and answers. We also provide reproducible baseline methods for the cQA task based on the resource, including deep learning models and personalization approaches. The results of the preliminary experiments conducted show the appropriateness of SE-PQA to train effective cQA models; they also show that personalization remarkably improves the effectiveness of all the methods tested. Furthermore, we show the benefits in terms of robustness and generalization of combining data from multiple communities for personalization purposes.

Utilizing ChatGPT to Enhance Clinical Trial Enrollment

Clinical trials are a critical component of evaluating the effectiveness of new medical interventions and driving advancements in medical research. Therefore, timely enrollment of patients is crucial to prevent delays or premature termination of trials. In this context, Electronic Health Records (EHRs) have emerged as a valuable tool for identifying and enrolling eligible participants. In this study, we propose an automated approach that leverages ChatGPT, a large language model, to extract patient-related information from unstructured clinical notes and generate search queries for retrieving potentially eligible clinical trials. Our empirical evaluation, conducted on two benchmark retrieval collections, shows improved retrieval performance compared to existing approaches when several general-purposed and task-specific prompts are used. Notably, ChatGPT-generated queries also outperform human-generated queries in terms of retrieval performance. These findings highlight the potential use of ChatGPT to enhance clinical trial enrollment while ensuring the quality of medical service and minimizing direct risks to patients.