Graph-based multimodal multi-lesion DLBCL treatment response prediction from PET images

Diffuse Large B-cell Lymphoma (DLBCL) is a lymphatic cancer involving one or more lymph nodes and extranodal sites. Its diagnostic and follow-up rely on Positron Emission Tomography (PET) and Computed Tomography (CT). After diagnosis, the number of nonresponding patients to standard front-line therapy remains significant (30-40%). This work aims to develop a computer-aided approach to identify high-risk patients requiring adapted treatment by efficiently exploiting all the information available for each patient, including both clinical and image data. We propose a method based on recent graph neural networks that combine imaging information from multiple lesions, and a cross-attention module to integrate different data modalities efficiently. The model is trained and evaluated on a private prospective multicentric dataset of 583 patients. Experimental results show that our proposed method outperforms classical supervised methods based on either clinical, imaging or both clinical and imaging data for the 2-year progression-free survival (PFS) classification accuracy.

Geometry-Aware Graph Transforms for Light Field Compact Representation

The paper addresses the problem of energy compaction of dense 4D light fields by designing geometry-aware local graph-based transforms. Local graphs are constructed on super-rays that can be seen as a grouping of spatially and geometry-dependent angularly correlated pixels. Both non separable and separable transforms are considered. Despite the local support of limited size defined by the super-rays, the Laplacian matrix of the non separable graph remains of high dimension and its diagonalization to compute the transform eigen vectors remains computationally expensive. To solve this problem, we then perform the local spatio-angular transform in a separable manner. We show that when the shape of corresponding super-pixels in the different views is not isometric, the basis functions of the spatial transforms are not coherent, resulting in decreased correlation between spatial transform coefficients. We hence propose a novel transform optimization method that aims at preserving angular correlation even when the shapes of the super-pixels are not isometric. Experimental results show the benefit of the approach in terms of energy compaction. A coding scheme is also described to assess the rate-distortion perfomances of the proposed transforms and is compared to state of the art encoders namely HEVC and JPEG Pleno VM 1.1.

Prediction and Sampling with Local Graph Transforms for Quasi-Lossless Light Field Compression

Graph-based transforms have been shown to be powerful tools in terms of image energy compaction. However, when the support increases to best capture signal dependencies, the computation of the basis functions becomes rapidly untractable. This problem is in particular compelling for high dimensional imaging data such as light fields. The use of local transforms with limited supports is a way to cope with this computational difficulty. Unfortunately, the locality of the support may not allow us to fully exploit long term signal dependencies present in both the spatial and angular dimensions in the case of light fields. This paper describes sampling and prediction schemes with local graph-based transforms enabling to efficiently compact the signal energy and exploit dependencies beyond the local graph support. The proposed approach is investigated and is shown to be very efficient in the context of spatio-angular transforms for quasi-lossless compression of light fields.