Terraced Compression Method with Automated Threshold Selection for Multidimensional Image Clustering of Heterogeneous Bodies

Multispectral transmission imaging provides strong benefits for early breast cancer screening. The frame accumulation method addresses the challenge of low grayscale and signal-to-noise ratio resulting from the strong absorption and scattering of light by breast tissue. This method introduces redundancy in data while improving the grayscale and signal-to-noise ratio of the image. Existing terraced compression algorithms effectively eliminate the data redundancy introduced by frame accumulation but necessitate significant time for manual debugging of threshold values. Hence, this paper proposes an improved terrace compression algorithm. The algorithm necessitates solely the input of the desired heterogeneous body size and autonomously calculates the optimal area threshold and gradient threshold by counting the grayscale and combining its distribution. Experimental acquisition involved multi-wavelength images of heterogeneous bodies exhibiting diverse textures, depths, and thicknesses. Subsequently, the method was applied after pre-processing to determine the thresholds for terraced compression at each wavelength, coupled with a window function for multi-dimensional image clustering. The results illustrate the method's efficacy in detecting and identifying various heterogeneous body types, depths, and thicknesses. This approach is expected to accurately identify the locations and types of breast tumors in the future, thus providing a more dependable tool for early breast cancer screening.

Learn Quasi-stationary Distributions of Finite State Markov Chain

We propose a reinforcement learning (RL) approach to compute the expression of quasi-stationary distribution. Based on the fixed-point formulation of quasi-stationary distribution, we minimize the KL-divergence of two Markovian path distributions induced by the candidate distribution and the true target distribution. To solve this challenging minimization problem by gradient descent, we apply the reinforcement learning technique by introducing the corresponding reward and value functions. We derive the corresponding policy gradient theorem and design an actor-critic algorithm to learn the optimal solution and value function. The numerical examples of finite state Markov chain are tested to demonstrate the new methods

The use of neural networks in the analysis of sleep stages and the diagnosis of narcolepsy

We used neural networks in ~3,000 sleep recordings from over 10 locations to automate sleep stage scoring, producing a probability distribution called an hypnodensity graph. Accuracy was validated in 70 subjects scored by six technicians (gold standard). Our best model performed better than any individual scorer, reaching an accuracy of 0.87 (and 0.95 when predictions are weighed by scorer agreement). It also scores sleep stages down to 5-second instead of the conventional 30-second scoring-epochs. Accuracy did not vary by sleep disorder except for narcolepsy, suggesting scoring difficulties by machine and/or humans. A narcolepsy biomarker was extracted and validated in 105 type-1 narcoleptics versus 331 controls producing a specificity of 0.96 and a sensitivity of 0.91. Similar performances were obtained against a high pretest probability sample of type-2 narcolepsy and idiopathic hypersomnia patients. Addition of HLA-DQB1*06:02 increased specificity to 0.99. Our method streamlines scoring and diagnoses narcolepsy accurately.