3D Distance-color-coded Assessment of PCI Stent Apposition via Deep-learning-based Three-dimensional Multi-object Segmentation

Coronary artery disease poses a significant global health challenge, often necessitating percutaneous coronary intervention (PCI) with stent implantation. Assessing stent apposition holds pivotal importance in averting and identifying PCI complications that lead to in-stent restenosis. Here we proposed a novel three-dimensional (3D) distance-color-coded assessment (DccA)for PCI stent apposition via deep-learning-based 3D multi-object segmentation in intravascular optical coherence tomography (IV-OCT). Our proposed 3D DccA accurately segments 3D vessel lumens and stents in IV-OCT images, using a spatial matching network and dual-layer training with style transfer. It quantifies and maps stent-lumen distances into a 3D color space, facilitating 3D visual assessment of PCI stent apposition. Achieving over 95% segmentation precision, our proposed DccA enhances clinical evaluation of PCI stent deployment and supports personalized treatment planning.

Toward ground-truth optical coherence tomography via three-dimensional unsupervised deep learning processing and data

Optical coherence tomography (OCT) can perform non-invasive high-resolution three-dimensional (3D) imaging and has been widely used in biomedical fields, while it is inevitably affected by coherence speckle noise which degrades OCT imaging performance and restricts its applications. Here we present a novel speckle-free OCT imaging strategy, named toward-ground-truth OCT (tGT-OCT), that utilizes unsupervised 3D deep-learning processing and leverages OCT 3D imaging features to achieve speckle-free OCT imaging. Specifically, our proposed tGT-OCT utilizes an unsupervised 3D-convolution deep-learning network trained using random 3D volumetric data to distinguish and separate speckle from real structures in 3D imaging volumetric space; moreover, tGT-OCT effectively further reduces speckle noise and reveals structures that would otherwise be obscured by speckle noise while preserving spatial resolution. Results derived from different samples demonstrated the high-quality speckle-free 3D imaging performance of tGT-OCT and its advancement beyond the previous state-of-the-art.