Overcoming the Domain Gap in Neural Action Representations

Relating animal behaviors to brain activity is a fundamental goal in neuroscience, with practical applications in building robust brain-machine interfaces. However, the domain gap between individuals is a major issue that prevents the training of general models that work on unlabeled subjects. Since 3D pose data can now be reliably extracted from multi-view video sequences without manual intervention, we propose to use it to guide the encoding of neural action representations together with a set of neural and behavioral augmentations exploiting the properties of microscopy imaging. To reduce the domain gap, during training, we swap neural and behavioral data across animals that seem to be performing similar actions. To demonstrate this, we test our methods on three very different multimodal datasets; one that features flies and their neural activity, one that contains human neural Electrocorticography (ECoG) data, and lastly the RGB video data of human activities from different viewpoints.

Overcoming the Domain Gap in Contrastive Learning of Neural Action Representations

A fundamental goal in neuroscience is to understand the relationship between neural activity and behavior. For example, the ability to extract behavioral intentions from neural data, or neural decoding, is critical for developing effective brain machine interfaces. Although simple linear models have been applied to this challenge, they cannot identify important non-linear relationships. Thus, a self-supervised means of identifying non-linear relationships between neural dynamics and behavior, in order to compute neural representations, remains an important open problem. To address this challenge, we generated a new multimodal dataset consisting of the spontaneous behaviors generated by fruit flies, Drosophila melanogaster -- a popular model organism in neuroscience research. The dataset includes 3D markerless motion capture data from six camera views of the animal generating spontaneous actions, as well as synchronously acquired two-photon microscope images capturing the activity of descending neuron populations that are thought to drive actions. Standard contrastive learning and unsupervised domain adaptation techniques struggle to learn neural action representations (embeddings computed from the neural data describing action labels) due to large inter-animal differences in both neural and behavioral modalities. To overcome this deficiency, we developed simple yet effective augmentations that close the inter-animal domain gap, allowing us to extract behaviorally relevant, yet domain agnostic, information from neural data. This multimodal dataset and our new set of augmentations promise to accelerate the application of self-supervised learning methods in neuroscience.