A Realistic Collimated X-Ray Image Simulation Pipeline

Collimator detection remains a challenging task in X-ray systems with unreliable or non-available information about the detectors position relative to the source. This paper presents a physically motivated image processing pipeline for simulating the characteristics of collimator shadows in X-ray images. By generating randomized labels for collimator shapes and locations, incorporating scattered radiation simulation, and including Poisson noise, the pipeline enables the expansion of limited datasets for training deep neural networks. We validate the proposed pipeline by a qualitative and quantitative comparison against real collimator shadows. Furthermore, it is demonstrated that utilizing simulated data within our deep learning framework not only serves as a suitable substitute for actual collimators but also enhances the generalization performance when applied to real-world data.

An Interpretable X-ray Style Transfer via Trainable Local Laplacian Filter

Radiologists have preferred visual impressions or 'styles' of X-ray images that are manually adjusted to their needs to support their diagnostic performance. In this work, we propose an automatic and interpretable X-ray style transfer by introducing a trainable version of the Local Laplacian Filter (LLF). From the shape of the LLF's optimized remap function, the characteristics of the style transfer can be inferred and reliability of the algorithm can be ensured. Moreover, we enable the LLF to capture complex X-ray style features by replacing the remap function with a Multi-Layer Perceptron (MLP) and adding a trainable normalization layer. We demonstrate the effectiveness of the proposed method by transforming unprocessed mammographic X-ray images into images that match the style of target mammograms and achieve a Structural Similarity Index (SSIM) of 0.94 compared to 0.82 of the baseline LLF style transfer method from Aubry et al.

StyleX: A Trainable Metric for X-ray Style Distances

The progression of X-ray technology introduces diverse image styles that need to be adapted to the preferences of radiologists. To support this task, we introduce a novel deep learning-based metric that quantifies style differences of non-matching image pairs. At the heart of our metric is an encoder capable of generating X-ray image style representations. This encoder is trained without any explicit knowledge of style distances by exploiting Simple Siamese learning. During inference, the style representations produced by the encoder are used to calculate a distance metric for non-matching image pairs. Our experiments investigate the proposed concept for a disclosed reproducible and a proprietary image processing pipeline along two dimensions: First, we use a t-distributed stochastic neighbor embedding (t-SNE) analysis to illustrate that the encoder outputs provide meaningful and discriminative style representations. Second, the proposed metric calculated from the encoder outputs is shown to quantify style distances for non-matching pairs in good alignment with the human perception. These results confirm that our proposed method is a promising technique to quantify style differences, which can be used for guided style selection as well as automatic optimization of image pipeline parameters.

Deep Learning-based Denoising of Mammographic Images using Physics-driven Data Augmentation

Mammography is using low-energy X-rays to screen the human breast and is utilized by radiologists to detect breast cancer. Typically radiologists require a mammogram with impeccable image quality for an accurate diagnosis. In this study, we propose a deep learning method based on Convolutional Neural Networks (CNNs) for mammogram denoising to improve the image quality. We first enhance the noise level and employ Anscombe Transformation (AT) to transform Poisson noise to white Gaussian noise. With this data augmentation, a deep residual network is trained to learn the noise map of the noisy images. We show, that the proposed method can remove not only simulated but also real noise. Furthermore, we also compare our results with state-of-the-art denoising methods, such as BM3D and DNCNN. In an early investigation, we achieved qualitatively better mammogram denoising results.