Deep Learning for Ophthalmology: The State-of-the-Art and Future Trends

The emergence of artificial intelligence (AI), particularly deep learning (DL), has marked a new era in the realm of ophthalmology, offering transformative potential for the diagnosis and treatment of posterior segment eye diseases. This review explores the cutting-edge applications of DL across a range of ocular conditions, including diabetic retinopathy, glaucoma, age-related macular degeneration, and retinal vessel segmentation. We provide a comprehensive overview of foundational ML techniques and advanced DL architectures, such as CNNs, attention mechanisms, and transformer-based models, highlighting the evolving role of AI in enhancing diagnostic accuracy, optimizing treatment strategies, and improving overall patient care. Additionally, we present key challenges in integrating AI solutions into clinical practice, including ensuring data diversity, improving algorithm transparency, and effectively leveraging multimodal data. This review emphasizes AI's potential to improve disease diagnosis and enhance patient care while stressing the importance of collaborative efforts to overcome these barriers and fully harness AI's impact in advancing eye care.

Towards Interpretable Radiology Report Generation via Concept Bottlenecks using a Multi-Agentic RAG

Deep learning has advanced medical image classification, but interpretability challenges hinder its clinical adoption. This study enhances interpretability in Chest X-ray (CXR) classification by using concept bottleneck models (CBMs) and a multi-agent Retrieval-Augmented Generation (RAG) system for report generation. By modeling relationships between visual features and clinical concepts, we create interpretable concept vectors that guide a multi-agent RAG system to generate radiology reports, enhancing clinical relevance, explainability, and transparency. Evaluation of the generated reports using an LLM-as-a-judge confirmed the interpretability and clinical utility of our model's outputs. On the COVID-QU dataset, our model achieved 81% classification accuracy and demonstrated robust report generation performance, with five key metrics ranging between 84% and 90%. This interpretable multi-agent framework bridges the gap between high-performance AI and the explainability required for reliable AI-driven CXR analysis in clinical settings.