BrainFuse: a unified infrastructure integrating realistic biological modeling and core AI methodology

Neuroscience and artificial intelligence represent distinct yet complementary pathways to general intelligence. However, amid the ongoing boom in AI research and applications, the translational synergy between these two fields has grown increasingly elusive-hampered by a widening infrastructural incompatibility: modern AI frameworks lack native support for biophysical realism, while neural simulation tools are poorly suited for gradient-based optimization and neuromorphic hardware deployment. To bridge this gap, we introduce BrainFuse, a unified infrastructure that provides comprehensive support for biophysical neural simulation and gradient-based learning. By addressing algorithmic, computational, and deployment challenges, BrainFuse exhibits three core capabilities: (1) algorithmic integration of detailed neuronal dynamics into a differentiable learning framework; (2) system-level optimization that accelerates customizable ion-channel dynamics by up to 3,000x on GPUs; and (3) scalable computation with highly compatible pipelines for neuromorphic hardware deployment. We demonstrate this full-stack design through both AI and neuroscience tasks, from foundational neuron simulation and functional cylinder modeling to real-world deployment and application scenarios. For neuroscience, BrainFuse supports multiscale biological modeling, enabling the deployment of approximately 38,000 Hodgkin-Huxley neurons with 100 million synapses on a single neuromorphic chip while consuming as low as 1.98 W. For AI, BrainFuse facilitates the synergistic application of realistic biological neuron models, demonstrating enhanced robustness to input noise and improved temporal processing endowed by complex HH dynamics. BrainFuse therefore serves as a foundational engine to facilitate cross-disciplinary research and accelerate the development of next-generation bio-inspired intelligent systems.

Resolving Ambiguity in Gaze-Facilitated Visual Assistant Interaction Paradigm

With the rise in popularity of smart glasses, users' attention has been integrated into Vision-Language Models (VLMs) to streamline multi-modal querying in daily scenarios. However, leveraging gaze data to model users' attention may introduce ambiguity challenges: (1) users' verbal questions become ambiguous by using pronouns or skipping context, (2) humans' gaze patterns can be noisy and exhibit complex spatiotemporal relationships with their spoken questions. Previous works only consider single image as visual modality input, failing to capture the dynamic nature of the user's attention. In this work, we introduce GLARIFY, a novel method to leverage spatiotemporal gaze information to enhance the model's effectiveness in real-world applications. Initially, we analyzed hundreds of querying samples with the gaze modality to demonstrate the noisy nature of users' gaze patterns. We then utilized GPT-4o to design an automatic data synthesis pipeline to generate the GLARIFY-Ambi dataset, which includes a dedicated chain-of-thought (CoT) process to handle noisy gaze patterns. Finally, we designed a heatmap module to incorporate gaze information into cutting-edge VLMs while preserving their pretrained knowledge. We evaluated GLARIFY using a hold-out test set. Experiments demonstrate that GLARIFY significantly outperforms baselines. By robustly aligning VLMs with human attention, GLARIFY paves the way for a usable and intuitive interaction paradigm with a visual assistant.

ZARA: Zero-shot Motion Time-Series Analysis via Knowledge and Retrieval Driven LLM Agents

Motion sensor time-series are central to human activity recognition (HAR), with applications in health, sports, and smart devices. However, existing methods are trained for fixed activity sets and require costly retraining when new behaviours or sensor setups appear. Recent attempts to use large language models (LLMs) for HAR, typically by converting signals into text or images, suffer from limited accuracy and lack verifiable interpretability. We propose ZARA, the first agent-based framework for zero-shot, explainable HAR directly from raw motion time-series. ZARA integrates an automatically derived pair-wise feature knowledge base that captures discriminative statistics for every activity pair, a multi-sensor retrieval module that surfaces relevant evidence, and a hierarchical agent pipeline that guides the LLM to iteratively select features, draw on this evidence, and produce both activity predictions and natural-language explanations. ZARA enables flexible and interpretable HAR without any fine-tuning or task-specific classifiers. Extensive experiments on 8 HAR benchmarks show that ZARA achieves SOTA zero-shot performance, delivering clear reasoning while exceeding the strongest baselines by 2.53x in macro F1. Ablation studies further confirm the necessity of each module, marking ZARA as a promising step toward trustworthy, plug-and-play motion time-series analysis. Our codes are available at https://github.com/zechenli03/ZARA.

Multi-Stage Verification-Centric Framework for Mitigating Hallucination in Multi-Modal RAG

This paper presents the technical solution developed by team CRUISE for the KDD Cup 2025 Meta Comprehensive RAG Benchmark for Multi-modal, Multi-turn (CRAG-MM) challenge. The challenge aims to address a critical limitation of modern Vision Language Models (VLMs): their propensity to hallucinate, especially when faced with egocentric imagery, long-tail entities, and complex, multi-hop questions. This issue is particularly problematic in real-world applications where users pose fact-seeking queries that demand high factual accuracy across diverse modalities. To tackle this, we propose a robust, multi-stage framework that prioritizes factual accuracy and truthfulness over completeness. Our solution integrates a lightweight query router for efficiency, a query-aware retrieval and summarization pipeline, a dual-pathways generation and a post-hoc verification. This conservative strategy is designed to minimize hallucinations, which incur a severe penalty in the competition's scoring metric. Our approach achieved 3rd place in Task 1, demonstrating the effectiveness of prioritizing answer reliability in complex multi-modal RAG systems. Our implementation is available at https://github.com/Breezelled/KDD-Cup-2025-Meta-CRAG-MM .

COMODO: Cross-Modal Video-to-IMU Distillation for Efficient Egocentric Human Activity Recognition

Egocentric video-based models capture rich semantic information and have demonstrated strong performance in human activity recognition (HAR). However, their high power consumption, privacy concerns, and dependence on lighting conditions limit their feasibility for continuous on-device recognition. In contrast, inertial measurement unit (IMU) sensors offer an energy-efficient and privacy-preserving alternative, yet they suffer from limited large-scale annotated datasets, leading to weaker generalization in downstream tasks. To bridge this gap, we propose COMODO, a cross-modal self-supervised distillation framework that transfers rich semantic knowledge from the video modality to the IMU modality without requiring labeled annotations. COMODO leverages a pretrained and frozen video encoder to construct a dynamic instance queue, aligning the feature distributions of video and IMU embeddings. By distilling knowledge from video representations, our approach enables the IMU encoder to inherit rich semantic information from video while preserving its efficiency for real-world applications. Experiments on multiple egocentric HAR datasets demonstrate that COMODO consistently improves downstream classification performance, achieving results comparable to or exceeding fully supervised fine-tuned models. Moreover, COMODO exhibits strong cross-dataset generalization. Benefiting from its simplicity, our method is also generally applicable to various video and time-series pre-trained models, offering the potential to leverage more powerful teacher and student foundation models in future research. The code is available at https://github.com/Breezelled/COMODO .

One-shot Training for Video Object Segmentation

Video Object Segmentation (VOS) aims to track objects across frames in a video and segment them based on the initial annotated frame of the target objects. Previous VOS works typically rely on fully annotated videos for training. However, acquiring fully annotated training videos for VOS is labor-intensive and time-consuming. Meanwhile, self-supervised VOS methods have attempted to build VOS systems through correspondence learning and label propagation. Still, the absence of mask priors harms their robustness to complex scenarios, and the label propagation paradigm makes them impractical in terms of efficiency. To address these issues, we propose, for the first time, a general one-shot training framework for VOS, requiring only a single labeled frame per training video and applicable to a majority of state-of-the-art VOS networks. Specifically, our algorithm consists of: i) Inferring object masks time-forward based on the initial labeled frame. ii) Reconstructing the initial object mask time-backward using the masks from step i). Through this bi-directional training, a satisfactory VOS network can be obtained. Notably, our approach is extremely simple and can be employed end-to-end. Finally, our approach uses a single labeled frame of YouTube-VOS and DAVIS datasets to achieve comparable results to those trained on fully labeled datasets. The code will be released.