Multi-Parameter Molecular MRI Quantification using Physics-Informed Self-Supervised Learning

Biophysical model fitting plays a key role in obtaining quantitative parameters from physiological signals and images. However, the model complexity for molecular magnetic resonance imaging (MRI) often translates into excessive computation time, which makes clinical use impractical. Here, we present a generic computational approach for solving the parameter extraction inverse problem posed by ordinary differential equation (ODE) modeling coupled with experimental measurement of the system dynamics. This is achieved by formulating a numerical ODE solver to function as a step-wise analytical one, thereby making it compatible with automatic differentiation-based optimization. This enables efficient gradient-based model fitting, and provides a new approach to parameter quantification based on self-supervised learning from a single data observation. The neural-network-based train-by-fit pipeline was used to quantify semisolid magnetization transfer (MT) and chemical exchange saturation transfer (CEST) amide proton exchange parameters in the human brain, in an in-vivo molecular MRI study (n=4). The entire pipeline of the first whole brain quantification was completed in 18.3$\pm$8.3 minutes, which is an order-of-magnitude faster than comparable alternatives. Reusing the single-subject-trained network for inference in new subjects took 1.0$\pm$0.2 s, to provide results in agreement with literature values and scan-specific fit results (Pearson's r>0.98, p<0.0001).

QFT: Post-training quantization via fast joint finetuning of all degrees of freedom

The post-training quantization (PTQ) challenge of bringing quantized neural net accuracy close to original has drawn much attention driven by industry demand. Many of the methods emphasize optimization of a specific degree-of-freedom (DoF), such as quantization step size, preconditioning factors, bias fixing, often chained to others in multi-step solutions. Here we rethink quantized network parameterization in HW-aware fashion, towards a unified analysis of all quantization DoF, permitting for the first time their joint end-to-end finetuning. Our single-step simple and extendable method, dubbed quantization-aware finetuning (QFT), achieves 4-bit weight quantization results on-par with SoTA within PTQ constraints of speed and resource.