This work proposes a new human-related video processing task named 3D panoramic multi-person localization and tracking. With a benchmark dataset and a simple yet effective solution, it establishes a new paradigm for multi-person tracking systems and related applications. Unlike existing methods that can only work on a 2D coordinate or a narrow-angle-view 3D coordinate, our proposal can maximally explore the 3D trajectory information of tracking targets. This is approached by applying camera geometry to transform human locations from 2D panoramic image coordinates to a 3D panoramic camera coordinate, and then by applying a tracking algorithm that associates human appearance and 3D trajectory together.