Explosive growth in spatio-temporal data and its wide range of applications have attracted increasing interests of researchers in the statistical and machine learning fields. The spatio-temporal regression problem is of paramount importance from both the methodology development and real-world application perspectives. Given the observed spatially encoded time series covariates and real-valued response data samples, the goal of spatio-temporal regression is to leverage the temporal and spatial dependencies to build a mapping from covariates to response with minimized prediction error. Prior arts, including the convolutional Long Short-Term Memory (CovLSTM) and variations of the functional linear models, cannot learn the spatio-temporal information in a simple and efficient format for proper model building. In this work, we propose two novel extensions of the Functional Neural Network (FNN), a temporal regression model whose effectiveness and superior performance over alternative sequential models have been proven by many researchers. The effectiveness of the proposed spatio-temporal FNNs in handling varying spatial correlations is demonstrated in comprehensive simulation studies. The proposed models are then deployed to solve a practical and challenging precipitation prediction problem in the meteorology field.