The standard paradigm for fake news detection mainly utilizes text information to model the truthfulness of news. However, the discourse of online fake news is typically subtle and it requires expert knowledge to use textual information to debunk fake news. Recently, studies focusing on multimodal fake news detection have outperformed text-only methods. Recent approaches utilizing the pre-trained model to extract unimodal features, or fine-tuning the pre-trained model directly, have become a new paradigm for detecting fake news. Again, this paradigm either requires a large number of training instances, or updates the entire set of pre-trained model parameters, making real-world fake news detection impractical. Furthermore, traditional multimodal methods fuse the cross-modal features directly without considering that the uncorrelated semantic representation might inject noise into the multimodal features. This paper proposes a Similarity-Aware Multimodal Prompt Learning (SAMPLE) framework. First, we incorporate prompt learning into multimodal fake news detection. Prompt learning, which only tunes prompts with a frozen language model, can reduce memory usage significantly and achieve comparable performances, compared with fine-tuning. We analyse three prompt templates with a soft verbalizer to detect fake news. In addition, we introduce the similarity-aware fusing method to adaptively fuse the intensity of multimodal representation and mitigate the noise injection via uncorrelated cross-modal features. For evaluation, SAMPLE surpasses the F1 and the accuracies of previous works on two benchmark multimodal datasets, demonstrating the effectiveness of the proposed method in detecting fake news. In addition, SAMPLE also is superior to other approaches regardless of few-shot and data-rich settings.