In computer vision, Image Difference Captioning (IDC) is crucial for accurately describing variations between closely related images. Traditional IDC methods often rely on specialist models, which restrict their applicability across varied contexts. This paper introduces the OneDiff model, a novel generalist approach that utilizes a robust vision-language model architecture, integrating a siamese image encoder with a Visual Delta Module. This innovative configuration allows for the precise detection and articulation of fine-grained differences between image pairs. OneDiff is trained through a dual-phase strategy, encompassing Coupled Sample Training and multi-task learning across a diverse array of data types, supported by our newly developed DiffCap Dataset. This dataset merges real-world and synthetic data, enhancing the training process and bolstering the model's robustness. Extensive testing on diverse IDC benchmarks, such as Spot-the-Diff, CLEVR-Change, and Birds-to-Words, shows that OneDiff consistently outperforms existing state-of-the-art models in accuracy and adaptability, achieving improvements of up to 85\% CIDEr points in average. By setting a new benchmark in IDC, OneDiff paves the way for more versatile and effective applications in detecting and describing visual differences. The code, models, and data will be made publicly available.