To enrich language models with domain knowledge is crucial but difficult. Based on the world's largest public academic graph Open Academic Graph (OAG), we pre-train an academic language model, namely OAG-BERT, which integrates massive heterogeneous entities including paper, author, concept, venue, and affiliation. To better endow OAG-BERT with the ability to capture entity information, we develop novel pre-training strategies including heterogeneous entity type embedding, entity-aware 2D positional encoding, and span-aware entity masking. For zero-shot inference, we design a special decoding strategy to allow OAG-BERT to generate entity names from scratch. We evaluate the OAG-BERT on various downstream academic tasks, including NLP benchmarks, zero-shot entity inference, heterogeneous graph link prediction, and author name disambiguation. Results demonstrate the effectiveness of the proposed pre-training approach to both comprehending academic texts and modeling knowledge from heterogeneous entities. OAG-BERT has been deployed to multiple real-world applications, such as reviewer recommendations and paper tagging in the AMiner system. It is also available to the public through the CogDL package.