Cross-Domain Few-Shot Object Detection (CD-FSOD) poses significant challenges to existing object detection and few-shot detection models when applied across domains. In conjunction with NTIRE 2025, we organized the 1st CD-FSOD Challenge, aiming to advance the performance of current object detectors on entirely novel target domains with only limited labeled data. The challenge attracted 152 registered participants, received submissions from 42 teams, and concluded with 13 teams making valid final submissions. Participants approached the task from diverse perspectives, proposing novel models that achieved new state-of-the-art (SOTA) results under both open-source and closed-source settings. In this report, we present an overview of the 1st NTIRE 2025 CD-FSOD Challenge, highlighting the proposed solutions and summarizing the results submitted by the participants.