Click-Through Rate (CTR) prediction, is an essential component of online advertising. The mainstream techniques mostly focus on feature interaction or user interest modeling, which rely on users' directly interacted items. The performance of these methods are usally impeded by inactive behaviours and system's exposure, incurring that the features extracted do not contain enough information to represent all potential interests. For this sake, we propose Neighbor-Interaction based CTR prediction, which put this task into a Heterogeneous Information Network (HIN) setting, then involves local neighborhood of the target user-item pair in the HIN to predict their linkage. In order to enhance the representation of the local neighbourhood, we consider four types of topological interaction among the nodes, and propose a novel Graph-masked Transformer architecture to effectively incorporates both feature and topological information. We conduct comprehensive experiments on two real world datasets and the experimental results show that our proposed method outperforms state-of-the-art CTR models significantly.