In this work, we propose a data generation pipeline by leveraging the 3D suite Blender to produce synthetic RGBD image datasets with 6D poses for robotic picking. The proposed pipeline can efficiently generate large amounts of photo-realistic RGBD images for the object of interest. In addition, a collection of domain randomization techniques is introduced to bridge the gap between real and synthetic data. Furthermore, we develop a real-time two-stage 6D pose estimation approach by integrating the object detector YOLO-V4-tiny and the 6D pose estimation algorithm PVN3D for time sensitive robotics applications. With the proposed data generation pipeline, our pose estimation approach can be trained from scratch using only synthetic data without any pre-trained models. The resulting network shows competitive performance compared to state-of-the-art methods when evaluated on LineMod dataset. We also demonstrate the proposed approach in a robotic experiment, grasping a household object from cluttered background under different lighting conditions.