Autonomous driving systems are increasingly popular in today's technological landscape, where vehicles with partial automation have already been widely available on the market, and the full automation era with ``driverless'' capabilities is near the horizon. However, accurately understanding humans' commands, particularly for autonomous vehicles that have only passengers instead of drivers, and achieving a high level of personalization remain challenging tasks in the development of autonomous driving systems. In this paper, we introduce a Large Language Model (LLM)-based framework Talk-to-Drive (Talk2Drive) to process verbal commands from humans and make autonomous driving decisions with contextual information, satisfying their personalized preferences for safety, efficiency, and comfort. First, a speech recognition module is developed for Talk2Drive to interpret verbal inputs from humans to textual instructions, which are then sent to LLMs for reasoning. Then, appropriate commands for the Electrical Control Unit (ECU) are generated, achieving a 100\% success rate in executing codes. Real-world experiments show that our framework can substantially reduce the takeover rate for a diverse range of drivers by up to 90.1\%. To the best of our knowledge, Talk2Drive marks the first instance of employing an LLM-based system in a real-world autonomous driving environment.