Out-of-distribution (OOD) generalisation aims to build a model that can well generalise its learnt knowledge from source domains to an unseen target domain. However, current image classification models often perform poorly in the OOD setting due to statistically spurious correlations learning from model training. From causality-based perspective, we formulate the data generation process in OOD image classification using a causal graph. On this graph, we show that prediction P(Y|X) of a label Y given an image X in statistical learning is formed by both causal effect P(Y|do(X)) and spurious effects caused by confounding features (e.g., background). Since the spurious features are domain-variant, the prediction P(Y|X) becomes unstable on unseen domains. In this paper, we propose to mitigate the spurious effect of confounders using front-door adjustment. In our method, the mediator variable is hypothesized as semantic features that are essential to determine a label for an image. Inspired by capability of style transfer in image generation, we interpret the combination of the mediator variable with different generated images in the front-door formula and propose novel algorithms to estimate it. Extensive experimental results on widely used benchmark datasets verify the effectiveness of our method.