Vehicle re-identification (Re-ID) is a crucial task in intelligent transportation systems (ITS), aimed at retrieving and matching the same vehicle across different surveillance cameras. Numerous studies have explored methods to enhance vehicle Re-ID by focusing on semantic enhancement. However, these methods often rely on additional annotated information to enable models to extract effective semantic features, which brings many limitations. In this work, we propose a CLIP-based Semantic Enhancement Network (CLIP-SENet), an end-to-end framework designed to autonomously extract and refine vehicle semantic attributes, facilitating the generation of more robust semantic feature representations. Inspired by zero-shot solutions for downstream tasks presented by large-scale vision-language models, we leverage the powerful cross-modal descriptive capabilities of the CLIP image encoder to initially extract general semantic information. Instead of using a text encoder for semantic alignment, we design an adaptive fine-grained enhancement module (AFEM) to adaptively enhance this general semantic information at a fine-grained level to obtain robust semantic feature representations. These features are then fused with common Re-ID appearance features to further refine the distinctions between vehicles. Our comprehensive evaluation on three benchmark datasets demonstrates the effectiveness of CLIP-SENet. Our approach achieves new state-of-the-art performance, with 92.9% mAP and 98.7% Rank-1 on VeRi-776 dataset, 90.4% Rank-1 and 98.7% Rank-5 on VehicleID dataset, and 89.1% mAP and 97.9% Rank-1 on the more challenging VeRi-Wild dataset.