Bioinformatics Retrieval Augmentation Data (BRAD) Digital Assistant

We present a prototype for a Bioinformatics Retrieval Augmentation Data (BRAD) digital assistant. BRAD integrates a suite of tools to handle a wide range of bioinformatics tasks, from code execution to online search. We demonstrate BRAD's capabilities through (1) improved question-and-answering with retrieval augmented generation (RAG), (2) BRAD's ability to run and write complex software pipelines, and (3) BRAD's ability to organize and distribute tasks across individual and teams of agents. We use BRAD for automation of bioinformatics workflows, performing tasks ranging from gene enrichment and searching the archive to automatic code generation and running biomarker identification pipelines. BRAD is a step toward the ultimate goal to develop a digital twin of laboratories driven by self-contained loops for hypothesis generation and testing of digital biology experiments.