Prohibited item detection is crucial for ensuring public safety, yet current X-ray image-based detection methods often lack comprehensive data-driven exploration. This paper introduces a novel data augmentation approach tailored for prohibited item detection, leveraging unique characteristics inherent to X-ray imagery. Our method is motivated by observations of physical properties including: 1) X-ray Transmission Imagery: Unlike reflected light images, transmitted X-ray pixels represent composite information from multiple materials along the imaging path. 2) Material-based Pseudo-coloring: Pseudo-color rendering in X-ray images correlates directly with material properties, aiding in material distinction. Building on a novel perspective from physical properties, we propose a simple yet effective X-ray image augmentation technique, Background Mixup (BGM), for prohibited item detection in security screening contexts. The essence is the rich background simulation of X-ray images to induce the model to increase its attention to the foreground. The approach introduces 1) contour information of baggage and 2) variation of material information into the original image by Mixup at patch level. Background Mixup is plug-and-play, parameter-free, highly generalizable and provides an effective solution to the limitations of classical visual augmentations in non-reflected light imagery. When implemented with different high-performance detectors, our augmentation method consistently boosts performance across diverse X-ray datasets from various devices and environments. Extensive experimental results demonstrate that our approach surpasses strong baselines while maintaining similar training resources.