The key to performance optimization of a program is to decide correctly when a certain transformation should be applied by a compiler. Traditionally, such profitability decisions are made by hand-coded algorithms tuned for a very small number of benchmarks, usually requiring a great deal of effort to be retuned when the benchmark suite changes. This is an ideal opportunity to apply machine-learning models to speed up the tuning process; while this realization has been around since the late 90s, only recent advancements in ML enabled a practical application of ML to compilers as an end-to-end framework. Even so, seamless integration of ML into the compiler would require constant rebuilding of the compiler when models are updated. This paper presents ACPO: \textbf{\underline{A}}I-Enabled \textbf{\underline{C}}ompiler-driven \textbf{\underline{P}}rogram \textbf{\underline{O}}ptimization; a novel framework to provide LLVM with simple and comprehensive tools to benefit from employing ML models for different optimization passes. We first showcase the high-level view, class hierarchy, and functionalities of ACPO and subsequently, demonstrate \taco{a couple of use cases of ACPO by ML-enabling the Loop Unroll and Function Inlining passes and describe how ACPO can be leveraged to optimize other passes. Experimental results reveal that ACPO model for Loop Unroll is able to gain on average 4\% and 3\%, 5.4\%, 0.2\% compared to LLVM's O3 optimization when deployed on Polybench, Coral-2, CoreMark, and Graph-500, respectively. Furthermore, by adding the Inliner model as well, ACPO is able to provide up to 4.5\% and 2.4\% on Polybench and Cbench compared with LLVM's O3 optimization, respectively.