Misinformation spans various domains, but detection methods trained on specific domains often perform poorly when applied to others. With the rapid development of Large Language Models (LLMs), researchers have begun to utilize LLMs for cross-domain misinformation detection. However, existing LLM-based methods often fail to adequately analyze news in the target domain, limiting their detection capabilities. More importantly, these methods typically rely on manually designed decision rules, which are limited by domain knowledge and expert experience, thus limiting the generalizability of decision rules to different domains. To address these issues, we propose a MultiAgent Framework for cross-domain misinformation detection with Automated Decision Rule Optimization (MARO). Under this framework, we first employs multiple expert agents to analyze target-domain news. Subsequently, we introduce a question-reflection mechanism that guides expert agents to facilitate higherquality analysis. Furthermore, we propose a decision rule optimization approach based on carefully-designed cross-domain validation tasks to iteratively enhance the effectiveness of decision rules in different domains. Experimental results and in-depth analysis on commonlyused datasets demonstrate that MARO achieves significant improvements over existing methods.