From Classification to Cross-Modal Understanding: Leveraging Vision-Language Models for Fine-Grained Renal Pathology

Fine-grained glomerular subtyping is central to kidney biopsy interpretation, but clinically valuable labels are scarce and difficult to obtain. Existing computational pathology approaches instead tend to evaluate coarse diseased classification under full supervision with image-only models, so it remains unclear how vision-language models (VLMs) should be adapted for clinically meaningful subtyping under data constraints. In this work, we model fine-grained glomerular subtyping as a clinically realistic few-shot problem and systematically evaluate both pathology-specialized and general-purpose vision-language models under this setting. We assess not only classification performance (accuracy, AUC, F1) but also the geometry of the learned representations, examining feature alignment between image and text embeddings and the separability of glomerular subtypes. By jointly analyzing shot count, model architecture and domain knowledge, and adaptation strategy, this study provides guidance for future model selection and training under real clinical data constraints. Our results indicate that pathology-specialized vision-language backbones, when paired with the vanilla fine-tuning, are the most effective starting point. Even with only 4-8 labeled examples per glomeruli subtype, these models begin to capture distinctions and show substantial gains in discrimination and calibration, though additional supervision continues to yield incremental improvements. We also find that the discrimination between positive and negative examples is as important as image-text alignment. Overall, our results show that supervision level and adaptation strategy jointly shape both diagnostic performance and multimodal structure, providing guidance for model selection, adaptation strategies, and annotation investment.

Struggle with Adversarial Defense? Try Diffusion

Adversarial attacks induce misclassification by introducing subtle perturbations. Recently, diffusion models are applied to the image classifiers to improve adversarial robustness through adversarial training or by purifying adversarial noise. However, diffusion-based adversarial training often encounters convergence challenges and high computational expenses. Additionally, diffusion-based purification inevitably causes data shift and is deemed susceptible to stronger adaptive attacks. To tackle these issues, we propose the Truth Maximization Diffusion Classifier (TMDC), a generative Bayesian classifier that builds upon pre-trained diffusion models and the Bayesian theorem. Unlike data-driven classifiers, TMDC, guided by Bayesian principles, utilizes the conditional likelihood from diffusion models to determine the class probabilities of input images, thereby insulating against the influences of data shift and the limitations of adversarial training. Moreover, to enhance TMDC's resilience against more potent adversarial attacks, we propose an optimization strategy for diffusion classifiers. This strategy involves post-training the diffusion model on perturbed datasets with ground-truth labels as conditions, guiding the diffusion model to learn the data distribution and maximizing the likelihood under the ground-truth labels. The proposed method achieves state-of-the-art performance on the CIFAR10 dataset against heavy white-box attacks and strong adaptive attacks. Specifically, TMDC achieves robust accuracies of 82.81% against $l_{\infty}$ norm-bounded perturbations and 86.05% against $l_{2}$ norm-bounded perturbations, respectively, with $\epsilon=0.05$.

URLBERT:A Contrastive and Adversarial Pre-trained Model for URL Classification

URLs play a crucial role in understanding and categorizing web content, particularly in tasks related to security control and online recommendations. While pre-trained models are currently dominating various fields, the domain of URL analysis still lacks specialized pre-trained models. To address this gap, this paper introduces URLBERT, the first pre-trained representation learning model applied to a variety of URL classification or detection tasks. We first train a URL tokenizer on a corpus of billions of URLs to address URL data tokenization. Additionally, we propose two novel pre-training tasks: (1) self-supervised contrastive learning tasks, which strengthen the model's understanding of URL structure and the capture of category differences by distinguishing different variants of the same URL; (2) virtual adversarial training, aimed at improving the model's robustness in extracting semantic features from URLs. Finally, our proposed methods are evaluated on tasks including phishing URL detection, web page classification, and ad filtering, achieving state-of-the-art performance. Importantly, we also explore multi-task learning with URLBERT, and experimental results demonstrate that multi-task learning model based on URLBERT exhibit equivalent effectiveness compared to independently fine-tuned models, showing the simplicity of URLBERT in handling complex task requirements. The code for our work is available at https://github.com/Davidup1/URLBERT.