Abstract:With the development of large language models (LLMs) like the GPT series, their widespread use across various application scenarios presents a myriad of challenges. This review initially explores the issue of domain specificity, where LLMs may struggle to provide precise answers to specialized questions within niche fields. The problem of knowledge forgetting arises as these LLMs might find it hard to balance old and new information. The knowledge repetition phenomenon reveals that sometimes LLMs might deliver overly mechanized responses, lacking depth and originality. Furthermore, knowledge illusion describes situations where LLMs might provide answers that seem insightful but are actually superficial, while knowledge toxicity focuses on harmful or biased information outputs. These challenges underscore problems in the training data and algorithmic design of LLMs. To address these issues, it's suggested to diversify training data, fine-tune models, enhance transparency and interpretability, and incorporate ethics and fairness training. Future technological trends might lean towards iterative methodologies, multimodal learning, model personalization and customization, and real-time learning and feedback mechanisms. In conclusion, future LLMs should prioritize fairness, transparency, and ethics, ensuring they uphold high moral and ethical standards when serving humanity.