Abstract:The lack of efficient segmentation methods and fully-labeled datasets limits the comprehensive assessment of optical coherence tomography angiography (OCTA) microstructures like retinal vessel network (RVN) and foveal avascular zone (FAZ), which are of great value in ophthalmic and systematic diseases evaluation. Here, we introduce an innovative OCTA microstructure segmentation network (OMSN) by combining an encoder-decoder-based architecture with multi-scale skip connections and the split-attention-based residual network ResNeSt, paying specific attention to OCTA microstructural features while facilitating better model convergence and feature representations. The proposed OMSN achieves excellent single/multi-task performances for RVN or/and FAZ segmentation. Especially, the evaluation metrics on multi-task models outperform single-task models on the same dataset. On this basis, a fully annotated retinal OCTA segmentation (FAROS) dataset is constructed semi-automatically, filling the vacancy of a pixel-level fully-labeled OCTA dataset. OMSN multi-task segmentation model retrained with FAROS further certifies its outstanding accuracy for simultaneous RVN and FAZ segmentation.