Multi-View Imputation and Cross-Attention Network Based on Incomplete Longitudinal and Multi-Modal Data for Alzheimer's Disease Prediction

Longitudinal variations and complementary information inherent in longitudinal and multi-modal data play an important role in Alzheimer's disease (AD) prediction, particularly in identifying subjects with mild cognitive impairment who are about to have AD. However, longitudinal and multi-modal data may have missing data, which hinders the effective application of these data. Additionally, previous longitudinal studies require existing longitudinal data to achieve prediction, but AD prediction is expected to be conducted at patients' baseline visit (BL) in clinical practice. Thus, we proposed a multi-view imputation and cross-attention network (MCNet) to integrate data imputation and AD prediction in a unified framework and achieve accurate AD prediction. First, a multi-view imputation method combined with adversarial learning, which can handle a wide range of missing data situations and reduce imputation errors, was presented. Second, two cross-attention blocks were introduced to exploit the potential associations in longitudinal and multi-modal data. Finally, a multi-task learning model was built for data imputation, longitudinal classification, and AD prediction tasks. When the model was properly trained, the disease progression information learned from longitudinal data can be leveraged by BL data to improve AD prediction. The proposed method was tested on two independent testing sets and single-model data at BL to verify its effectiveness and flexibility on AD prediction. Results showed that MCNet outperformed several state-of-the-art methods. Moreover, the interpretability of MCNet was presented. Thus, our MCNet is a tool with a great application potential in longitudinal and multi-modal data analysis for AD prediction. Codes are available at https://github.com/Meiyan88/MCNET.

Semi-Supervised Hybrid Spine Network for Segmentation of Spine MR Images

Automatic segmentation of vertebral bodies (VBs) and intervertebral discs (IVDs) in 3D magnetic resonance (MR) images is vital in diagnosing and treating spinal diseases. However, segmenting the VBs and IVDs simultaneously is not trivial. Moreover, problems exist, including blurry segmentation caused by anisotropy resolution, high computational cost, inter-class similarity and intra-class variability, and data imbalances. We proposed a two-stage algorithm, named semi-supervised hybrid spine network (SSHSNet), to address these problems by achieving accurate simultaneous VB and IVD segmentation. In the first stage, we constructed a 2D semi-supervised DeepLabv3+ by using cross pseudo supervision to obtain intra-slice features and coarse segmentation. In the second stage, a 3D full-resolution patch-based DeepLabv3+ was built. This model can be used to extract inter-slice information and combine the coarse segmentation and intra-slice features provided from the first stage. Moreover, a cross tri-attention module was applied to compensate for the loss of inter-slice and intra-slice information separately generated from 2D and 3D networks, thereby improving feature representation ability and achieving satisfactory segmentation results. The proposed SSHSNet was validated on a publicly available spine MR image dataset, and remarkable segmentation performance was achieved. Moreover, results show that the proposed method has great potential in dealing with the data imbalance problem. Based on previous reports, few studies have incorporated a semi-supervised learning strategy with a cross attention mechanism for spine segmentation. Therefore, the proposed method may provide a useful tool for spine segmentation and aid clinically in spinal disease diagnoses and treatments. Codes are publicly available at: https://github.com/Meiyan88/SSHSNet.