A Shape-Based Functional Index for Objective Assessment of Pediatric Motor Function

Clinical assessments for neuromuscular disorders, such as Spinal Muscular Atrophy (SMA) and Duchenne Muscular Dystrophy (DMD), continue to rely on subjective measures to monitor treatment response and disease progression. We introduce a novel method using wearable sensors to objectively assess motor function during daily activities in 19 patients with DMD, 9 with SMA, and 13 age-matched controls. Pediatric movement data is complex due to confounding factors such as limb length variations in growing children and variability in movement speed. Our approach uses Shape-based Principal Component Analysis to align movement trajectories and identify distinct kinematic patterns, including variations in motion speed and asymmetry. Both DMD and SMA cohorts have individuals with motor function on par with healthy controls. Notably, patients with SMA showed greater activation of the motion asymmetry pattern. We further combined projections on these principal components with partial least squares (PLS) to identify a covariation mode with a canonical correlation of r = 0.78 (95% CI: [0.34, 0.94]) with muscle fat infiltration, the Brooke score (a motor function score), and age-related degenerative changes, proposing a novel motor function index. This data-driven method can be deployed in home settings, enabling better longitudinal tracking of treatment efficacy for children with neuromuscular disorders.

Graph Neural Networks in IoT: A Survey

The Internet of Things (IoT) boom has revolutionized almost every corner of people's daily lives: healthcare, home, transportation, manufacturing, supply chain, and so on. With the recent development of sensor and communication technologies, IoT devices including smart wearables, cameras, smartwatches, and autonomous vehicles can accurately measure and perceive their surrounding environment. Continuous sensing generates massive amounts of data and presents challenges for machine learning. Deep learning models (e.g., convolution neural networks and recurrent neural networks) have been extensively employed in solving IoT tasks by learning patterns from multi-modal sensory data. Graph Neural Networks (GNNs), an emerging and fast-growing family of neural network models, can capture complex interactions within sensor topology and have been demonstrated to achieve state-of-the-art results in numerous IoT learning tasks. In this survey, we present a comprehensive review of recent advances in the application of GNNs to the IoT field, including a deep dive analysis of GNN design in various IoT sensing environments, an overarching list of public data and source code from the collected publications, and future research directions. To keep track of newly published works, we collect representative papers and their open-source implementations and create a Github repository at https://github.com/GuiminDong/GNN4IoT.