Abstract:Objective: Social Determinants of Health (SDOH) influence personal health outcomes and health systems interactions. Health systems capture SDOH information through structured data and unstructured clinical notes; however, clinical notes often contain a more comprehensive representation of several key SDOH. The objective of this work is to assess the SDOH information gain achievable by extracting structured semantic representations of SDOH from the clinical narrative and combining these extracted representations with available structured data. Materials and Methods: We developed a natural language processing (NLP) information extraction model for SDOH that utilizes a deep learning entity and relation extraction architecture. In an electronic health record (EHR) case study, we applied the SDOH extractor to a large existing clinical data set with over 200,000 patients and 400,000 notes and compared the extracted information with available structured data. Results: The SDOH extractor achieved 0.86 F1 on a withheld test set. In the EHR case study, we found 19\% of current tobacco users, 10\% of drug users, and 32\% of homeless patients only include documentation of these risk factors in the clinical narrative. Conclusions: Patients who are at-risk for negative health outcomes due to SDOH may be better served if health systems are able to identify SDOH risk factors and associated social needs. Structured semantic representations of text-encoded SDOH information can augment existing structured, and this more comprehensive SDOH representation can assist health systems in identifying and addressing social needs.