A Survey on Hypothesis Generation for Scientific Discovery in the Era of Large Language Models

Hypothesis generation is a fundamental step in scientific discovery, yet it is increasingly challenged by information overload and disciplinary fragmentation. Recent advances in Large Language Models (LLMs) have sparked growing interest in their potential to enhance and automate this process. This paper presents a comprehensive survey of hypothesis generation with LLMs by (i) reviewing existing methods, from simple prompting techniques to more complex frameworks, and proposing a taxonomy that categorizes these approaches; (ii) analyzing techniques for improving hypothesis quality, such as novelty boosting and structured reasoning; (iii) providing an overview of evaluation strategies; and (iv) discussing key challenges and future directions, including multimodal integration and human-AI collaboration. Our survey aims to serve as a reference for researchers exploring LLMs for hypothesis generation.

Using Large Language Models for Automated Grading of Student Writing about Science

Assessing writing in large classes for formal or informal learners presents a significant challenge. Consequently, most large classes, particularly in science, rely on objective assessment tools such as multiple-choice quizzes, which have a single correct answer. The rapid development of AI has introduced the possibility of using large language models (LLMs) to evaluate student writing. An experiment was conducted using GPT-4 to determine if machine learning methods based on LLMs can match or exceed the reliability of instructor grading in evaluating short writing assignments on topics in astronomy. The audience consisted of adult learners in three massive open online courses (MOOCs) offered through Coursera. One course was on astronomy, the second was on astrobiology, and the third was on the history and philosophy of astronomy. The results should also be applicable to non-science majors in university settings, where the content and modes of evaluation are similar. The data comprised answers from 120 students to 12 questions across the three courses. GPT-4 was provided with total grades, model answers, and rubrics from an instructor for all three courses. In addition to evaluating how reliably the LLM reproduced instructor grades, the LLM was also tasked with generating its own rubrics. Overall, the LLM was more reliable than peer grading, both in aggregate and by individual student, and approximately matched instructor grades for all three online courses. The implication is that LLMs may soon be used for automated, reliable, and scalable grading of student science writing.

Estimating Dark Matter Halo Masses in Simulated Galaxy Clusters with Graph Neural Networks

Galaxies grow and evolve in dark matter halos. Because dark matter is not visible, galaxies' halo masses ($\rm{M}_{\rm{halo}}$) must be inferred indirectly. We present a graph neural network (GNN) model for predicting $\rm{M}_{\rm{halo}}$ from stellar mass ($\rm{M}_{*}$) in simulated galaxy clusters using data from the IllustrisTNG simulation suite. Unlike traditional machine learning models like random forests, our GNN captures the information-rich substructure of galaxy clusters by using spatial and kinematic relationships between galaxy neighbour. A GNN model trained on the TNG-Cluster dataset and independently tested on the TNG300 simulation achieves superior predictive performance compared to other baseline models we tested. Future work will extend this approach to different simulations and real observational datasets to further validate the GNN model's ability to generalise.

Grading Massive Open Online Courses Using Large Language Models

Massive open online courses (MOOCs) offer free education globally to anyone with a computer and internet access. Despite this democratization of learning, the massive enrollment in these courses makes it impractical for one instructor to assess every student's writing assignment. As a result, peer grading, often guided by a straightforward rubric, is the method of choice. While convenient, peer grading often falls short in terms of reliability and validity. In this study, we explore the feasibility of using large language models (LLMs) to replace peer grading in MOOCs. Specifically, we use two LLMs, GPT-4 and GPT-3.5, across three MOOCs: Introductory Astronomy, Astrobiology, and the History and Philosophy of Astronomy. To instruct LLMs, we use three different prompts based on the zero-shot chain-of-thought (ZCoT) prompting technique: (1) ZCoT with instructor-provided correct answers, (2) ZCoT with both instructor-provided correct answers and rubrics, and (3) ZCoT with instructor-provided correct answers and LLM-generated rubrics. Tested on 18 settings, our results show that ZCoT, when augmented with instructor-provided correct answers and rubrics, produces grades that are more aligned with those assigned by instructors compared to peer grading. Finally, our findings indicate a promising potential for automated grading systems in MOOCs, especially in subjects with well-defined rubrics, to improve the learning experience for millions of online learners worldwide.

Large Language Models As MOOCs Graders

Massive open online courses (MOOCs) unlock the doors to free education for anyone around the globe with access to a computer and the internet. Despite this democratization of learning, the massive enrollment in these courses means it is almost impossible for one instructor to assess every student's writing assignment. As a result, peer grading, often guided by a straightforward rubric, is the method of choice. While convenient, peer grading often falls short in terms of reliability and validity. In this study, using 18 distinct settings, we explore the feasibility of leveraging large language models (LLMs) to replace peer grading in MOOCs. Specifically, we focus on two state-of-the-art LLMs: GPT-4 and GPT-3.5, across three distinct courses: Introductory Astronomy, Astrobiology, and the History and Philosophy of Astronomy. To instruct LLMs, we use three different prompts based on a variant of the zero-shot chain-of-thought (Zero-shot-CoT) prompting technique: Zero-shot-CoT combined with instructor-provided correct answers; Zero-shot-CoT in conjunction with both instructor-formulated answers and rubrics; and Zero-shot-CoT with instructor-offered correct answers and LLM-generated rubrics. Our results show that Zero-shot-CoT, when integrated with instructor-provided answers and rubrics, produces grades that are more aligned with those assigned by instructors compared to peer grading. However, the History and Philosophy of Astronomy course proves to be more challenging in terms of grading as opposed to other courses. Finally, our study reveals a promising direction for automating grading systems for MOOCs, especially in subjects with well-defined rubrics.