PseudoCell: Hard Negative Mining as Pseudo Labeling for Deep Learning-Based Centroblast Cell Detection

Patch classification models based on deep learning have been utilized in whole-slide images (WSI) of H&E-stained tissue samples to assist pathologists in grading follicular lymphoma patients. However, these approaches still require pathologists to manually identify centroblast cells and provide refined labels for optimal performance. To address this, we propose PseudoCell, an object detection framework to automate centroblast detection in WSI (source code is available at https://github.com/IoBT-VISTEC/PseudoCell.git). This framework incorporates centroblast labels from pathologists and combines them with pseudo-negative labels obtained from undersampled false-positive predictions using the cell's morphological features. By employing PseudoCell, pathologists' workload can be reduced as it accurately narrows down the areas requiring their attention during examining tissue. Depending on the confidence threshold, PseudoCell can eliminate 58.18-99.35% of non-centroblasts tissue areas on WSI. This study presents a practical centroblast prescreening method that does not require pathologists' refined labels for improvement. Detailed guidance on the practical implementation of PseudoCell is provided in the discussion section.

PACMAN: a framework for pulse oximeter digit detection and reading in a low-resource setting

In light of the COVID-19 pandemic, patients were required to manually input their daily oxygen saturation (SpO2) and pulse rate (PR) values into a health monitoring system-unfortunately, such a process trend to be an error in typing. Several studies attempted to detect the physiological value from the captured image using optical character recognition (OCR). However, the technology has limited availability with high cost. Thus, this study aimed to propose a novel framework called PACMAN (Pandemic Accelerated Human-Machine Collaboration) with a low-resource deep learning-based computer vision. We compared state-of-the-art object detection algorithms (scaled YOLOv4, YOLOv5, and YOLOR), including the commercial OCR tools for digit recognition on the captured images from pulse oximeter display. All images were derived from crowdsourced data collection with varying quality and alignment. YOLOv5 was the best-performing model against the given model comparison across all datasets, notably the correctly orientated image dataset. We further improved the model performance with the digits auto-orientation algorithm and applied a clustering algorithm to extract SpO2 and PR values. The accuracy performance of YOLOv5 with the implementations was approximately 81.0-89.5%, which was enhanced compared to without any additional implementation. Accordingly, this study highlighted the completion of PACMAN framework to detect and read digits in real-world datasets. The proposed framework has been currently integrated into the patient monitoring system utilized by hospitals nationwide.