From General to Specific: Tailoring Large Language Models for Personalized Healthcare

The rapid development of large language models (LLMs) has transformed many industries, including healthcare. However, previous medical LLMs have largely focused on leveraging general medical knowledge to provide responses, without accounting for patient variability and lacking true personalization at the individual level. To address this, we propose a novel method called personalized medical language model (PMLM), which explores and optimizes personalized LLMs through recommendation systems and reinforcement learning (RL). Specifically, by utilizing self-informed and peer-informed personalization, PMLM captures changes in behaviors and preferences to design initial personalized prompts tailored to individual needs. We further refine these initial personalized prompts through RL, ultimately enhancing the precision of LLM guidance. Notably, the personalized prompt are hard prompt, which grants PMLM high adaptability and reusability, allowing it to directly leverage high-quality proprietary LLMs. We evaluate PMLM using real-world obstetrics and gynecology data, and the experimental results demonstrate that PMLM achieves personalized responses, and it provides more refined and individualized services, offering a potential way for personalized medical LLMs.

OCDB: Revisiting Causal Discovery with a Comprehensive Benchmark and Evaluation Framework

Large language models (LLMs) have excelled in various natural language processing tasks, but challenges in interpretability and trustworthiness persist, limiting their use in high-stakes fields. Causal discovery offers a promising approach to improve transparency and reliability. However, current evaluations are often one-sided and lack assessments focused on interpretability performance. Additionally, these evaluations rely on synthetic data and lack comprehensive assessments of real-world datasets. These lead to promising methods potentially being overlooked. To address these issues, we propose a flexible evaluation framework with metrics for evaluating differences in causal structures and causal effects, which are crucial attributes that help improve the interpretability of LLMs. We introduce the Open Causal Discovery Benchmark (OCDB), based on real data, to promote fair comparisons and drive optimization of algorithms. Additionally, our new metrics account for undirected edges, enabling fair comparisons between Directed Acyclic Graphs (DAGs) and Completed Partially Directed Acyclic Graphs (CPDAGs). Experimental results show significant shortcomings in existing algorithms' generalization capabilities on real data, highlighting the potential for performance improvement and the importance of our framework in advancing causal discovery techniques.