Abstract:Multimodal medical data fusion has emerged as a transformative approach in smart healthcare, enabling a comprehensive understanding of patient health and personalized treatment plans. In this paper, a journey from data, information, and knowledge to wisdom (DIKW) is explored through multimodal fusion for smart healthcare. A comprehensive review of multimodal medical data fusion focuses on the integration of various data modalities are presented. It explores different approaches such as Feature selection, Rule-based systems, Machine learning, Deep learning, and Natural Language Processing for fusing and analyzing multimodal data. The paper also highlights the challenges associated with multimodal fusion in healthcare. By synthesizing the reviewed frameworks and insights, a generic framework for multimodal medical data fusion is proposed while aligning with the DIKW mechanism. Moreover, it discusses future directions aligned with the four pillars of healthcare: Predictive, Preventive, Personalized, and Participatory approaches based on the DIKW and the generic framework. The components from this comprehensive survey form the foundation for the successful implementation of multimodal fusion in smart healthcare. The findings of this survey can guide researchers and practitioners in leveraging the power of multimodal fusion with the approaches to revolutionize healthcare and improve patient outcomes.