Machine Learning Driven Biomarker Selection for Medical Diagnosis

Recent advances in experimental methods have enabled researchers to collect data on thousands of analytes simultaneously. This has led to correlational studies that associated molecular measurements with diseases such as Alzheimer's, Liver, and Gastric Cancer. However, the use of thousands of biomarkers selected from the analytes is not practical for real-world medical diagnosis and is likely undesirable due to potentially formed spurious correlations. In this study, we evaluate 4 different methods for biomarker selection and 4 different machine learning (ML) classifiers for identifying correlations, evaluating 16 approaches in all. We found that contemporary methods outperform previously reported logistic regression in cases where 3 and 10 biomarkers are permitted. When specificity is fixed at 0.9, ML approaches produced a sensitivity of 0.240 (3 biomarkers) and 0.520 (10 biomarkers), while standard logistic regression provided a sensitivity of 0.000 (3 biomarkers) and 0.040 (10 biomarkers). We also noted that causal-based methods for biomarker selection proved to be the most performant when fewer biomarkers were permitted, while univariate feature selection was the most performant when a greater number of biomarkers were permitted.

An optimization method for out-of-distribution anomaly detection models

Frequent false alarms impede the promotion of unsupervised anomaly detection algorithms in industrial applications. Potential characteristics of false alarms depending on the trained detector are revealed by investigating density probability distributions of prediction scores in the out-of-distribution anomaly detection tasks. An SVM-based classifier is exploited as a post-processing module to identify false alarms from the anomaly map at the object level. Besides, a sample synthesis strategy is devised to incorporate fuzzy prior knowledge on the specific application in the anomaly-free training dataset. Experimental results illustrate that the proposed method comprehensively improves the performances of two segmentation models at both image and pixel levels on two industrial applications.