GBT-SAM: A Parameter-Efficient Depth-Aware Model for Generalizable Brain tumour Segmentation on mp-MRI

Gliomas are brain tumours that stand out for their highly lethal and aggressive nature, which demands a precise approach in their diagnosis. Medical image segmentation plays a crucial role in the evaluation and follow-up of these tumours, allowing specialists to analyse their morphology. However, existing methods for automatic glioma segmentation often lack generalization capability across other brain tumour domains, require extensive computational resources, or fail to fully utilize the multi-parametric MRI (mp-MRI) data used to delineate them. In this work, we introduce GBT-SAM, a novel Generalizable Brain Tumour (GBT) framework that extends the Segment Anything Model (SAM) to brain tumour segmentation tasks. Our method employs a two-step training protocol: first, fine-tuning the patch embedding layer to process the entire mp-MRI modalities, and second, incorporating parameter-efficient LoRA blocks and a Depth-Condition block into the Vision Transformer (ViT) to capture inter-slice correlations. GBT-SAM achieves state-of-the-art performance on the Adult Glioma dataset (Dice Score of $93.54$) while demonstrating robust generalization across Meningioma, Pediatric Glioma, and Sub-Saharan Glioma datasets. Furthermore, GBT-SAM uses less than 6.5M trainable parameters, thus offering an efficient solution for brain tumour segmentation. \\ Our code and models are available at https://github.com/vpulab/med-sam-brain .

VLMs meet UDA: Boosting Transferability of Open Vocabulary Segmentation with Unsupervised Domain Adaptation

Segmentation models are typically constrained by the categories defined during training. To address this, researchers have explored two independent approaches: adapting Vision-Language Models (VLMs) and leveraging synthetic data. However, VLMs often struggle with granularity, failing to disentangle fine-grained concepts, while synthetic data-based methods remain limited by the scope of available datasets. This paper proposes enhancing segmentation accuracy across diverse domains by integrating Vision-Language reasoning with key strategies for Unsupervised Domain Adaptation (UDA). First, we improve the fine-grained segmentation capabilities of VLMs through multi-scale contextual data, robust text embeddings with prompt augmentation, and layer-wise fine-tuning in our proposed Foundational-Retaining Open Vocabulary Semantic Segmentation (FROVSS) framework. Next, we incorporate these enhancements into a UDA framework by employing distillation to stabilize training and cross-domain mixed sampling to boost adaptability without compromising generalization. The resulting UDA-FROVSS framework is the first UDA approach to effectively adapt across domains without requiring shared categories.