Deep learning and whole-brain networks for biomarker discovery: modeling the dynamics of brain fluctuations in resting-state and cognitive tasks

Background: Brain network models offer insights into brain dynamics, but the utility of model-derived bifurcation parameters as biomarkers remains underexplored. Objective: This study evaluates bifurcation parameters from a whole-brain network model as biomarkers for distinguishing brain states associated with resting-state and task-based cognitive conditions. Methods: Synthetic BOLD signals were generated using a supercritical Hopf brain network model to train deep learning models for bifurcation parameter prediction. Inference was performed on Human Connectome Project data, including both resting-state and task-based conditions. Statistical analyses assessed the separability of brain states based on bifurcation parameter distributions. Results: Bifurcation parameter distributions differed significantly across task and resting-state conditions ($p < 0.0001$ for all but one comparison). Task-based brain states exhibited higher bifurcation values compared to rest. Conclusion: Bifurcation parameters effectively differentiate cognitive and resting states, warranting further investigation as biomarkers for brain state characterization and neurological disorder assessment.

Assessing the impact of machine intelligence on human behaviour: an interdisciplinary endeavour

This document contains the outcome of the first Human behaviour and machine intelligence (HUMAINT) workshop that took place 5-6 March 2018 in Barcelona, Spain. The workshop was organized in the context of a new research programme at the Centre for Advanced Studies, Joint Research Centre of the European Commission, which focuses on studying the potential impact of artificial intelligence on human behaviour. The workshop gathered an interdisciplinary group of experts to establish the state of the art research in the field and a list of future research challenges to be addressed on the topic of human and machine intelligence, algorithm's potential impact on human cognitive capabilities and decision making, and evaluation and regulation needs. The document is made of short position statements and identification of challenges provided by each expert, and incorporates the result of the discussions carried out during the workshop. In the conclusion section, we provide a list of emerging research topics and strategies to be addressed in the near future.