Artificial neural networks in action for an automated cell-type classification of biological neural networks

In this work we address the problem of neuronal cell-type classification, and we employ a real-world dataset of raw neuronal activity measurements obtained with calcium imaging techniques. While neuronal cell-type classification is a crucial step in understanding the function of neuronal circuits, and thus a systematic classification of neurons is much needed, it still remains a challenge. In recent years, several approaches have been employed for a reliable neuronal cell-type recognition, such as immunohistochemical (IHC) analysis and feature extraction algorithms based on several characteristics of neuronal cells. These methods, however, demand a lot of human intervention and observation, they are time-consuming and regarding the feature extraction algorithms it is not clear or obvious what are the best features that define a neuronal cell class. In this work we examine three different deep learning models aiming at an automated neuronal cell-type classification and compare their performance. Experimental analysis demonstrates the efficacy and potent capabilities for each one of the proposed schemes.