Abstract:DTC is a technical system that reflects the raw channel fading states and variations in a digital form at the virtual space, to actively adapt to novel communication techniques of the wireless communication system (WCS) at the physical or link level. To realize DTC, in this article, the concept and construction method of the radio environment knowledge pool (REKP) is proposed, which possesses the advantages of being controllable, interpretable, renewable, and generalized. Concretely, it is a collection that represents the regular pattern representations and interconnections between propagation environment information (PEI) and channel data. It also has the ability to update knowledge based on environment changes, human cognition, and technological developments. Firstly, the current state of knowledge-based research in the communication field and that for acquiring channel knowledge and achieving DTC are summarized. Secondly, how to construct and update REKP to conduct key communication tasks is given. Then, the typical cases with extensive numerical results are presented to demonstrate the great potential of REKP in enabling DTC. Finally, how to utilize REKP to address key challenges in implementing DTC and 6G WCS are discussed, including interpretability and generalization of DTC, and enhancing performance and reducing costs in the 6G WCS.