Hidden Markov Models for sepsis detection in preterm infants

We explore the use of traditional and contemporary hidden Markov models (HMMs) for sequential physiological data analysis and sepsis prediction in preterm infants. We investigate the use of classical Gaussian mixture model based HMM, and a recently proposed neural network based HMM. To improve the neural network based HMM, we propose a discriminative training approach. Experimental results show the potential of HMMs over logistic regression, support vector machine and extreme learning machine.

Large Neural Network Based Detection of Apnea, Bradycardia and Desaturation Events

Apnea, bradycardia and desaturation (ABD) events often precede life-threatening events including sepsis in newborn babies. Here, we explore machine learning for detection of ABD events as a binary classification problem. We investigate the use of a large neural network to achieve a good detection performance. To be user friendly, the chosen neural network does not require a high level of parameter tuning. Furthermore, a limited amount of training data is available and the training dataset is unbalanced. Comparing with two widely used state-of-the-art machine learning algorithms, the large neural network is found to be efficient. Even with a limited and unbalanced training data, the large neural network provides a detection performance level that is feasible to use in clinical care.